Modified virus having an altered tropism

Details Modified virus having an altered tropism Modified virus having an altered tropism

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 35/76 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2413851

The present invention describes a modified virus comprising one or more non- native polypeptides, which polypeptide comprises one or more framework moieties each containing one or more biding moieties, which polypeptides is capable of being expressed in the cytoplasm and nucleus of a mammalian host cell in a conformation which is maintained in the absence of a ligand for said binding moieties, said conformation allowing said binding moieties subsequently to bind with said ligand, and which polypeptide is capable of transport through the nuclear membrane, wherein said modified virus has an altered tropism conferred by said binding moieties and the use of such viruses in the therapy, particularly in the treatment of tumours or other cancerous cells.

La présente invention concerne un virus modifié comprenant un ou plusieurs polypeptides non natifs, lequel polypeptide comprend une ou plusieurs structures de groupes caractéristiques contenant chacune un ou plusieurs groupes caractéristiques de liaison, lequel polypeptide peut être exprimé dans le cytoplasme et le noyau d'une cellule hôte de mammifère dans une conformation qui est maintenue en l'absence d'un ligand pour lesdits groupes caractéristiques de liaison, ladite conformation permettant auxdits groupes caractéristiques de liaison de se lier ensuite avec ledit ligand et lequel polypeptide est capable de transport malgré la membrane nucléaire, dans laquelle ledit virus modifié présente un tropisme modifié conféré par lesdits groupes caractéristiques de liaison. L'invention concerne également l'utilisation de tels virus à des fins thérapeutiques, particulièrement dans le traitement de tumeurs ou d'autres cellules cancéreuses.

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