Modified vp1/p2a region of the rhinovirus system

Details Modified vp1/p2a region of the rhinovirus system Modified vp1/p2a region of the rhinovirus system

C - Chemistry, Metallurgy

12

N

530/7.1, 195/1.1

C12N 15/41 (2006.01) C07H 21/00 (2006.01) C07K 14/095 (2006.01) C07K 16/08 (2006.01) C12Q 1/68 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2019661

Abstract The present invention relates to systems which make it possible to introduce mutations in the VPl/2A and in the overall coding region of the protease 2A, test systems by means of which the "cis" and "trans" activity can be investigated, oligonucleotides which code the mutations, as well as the oligopeptides derived therefrom and their use. It further relates to oligopeptides which are cleaved by protease 2A in trans with varying degrees of efficiency, and the use thereof.

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