Modifying the control of gene expression behavior by the...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/63 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2492124

The connectron structure of a genome determines sets of four DNA sequences of minimum length of 15-bases (Cl and C2 which are in the 3'UTR of a gene, T1 which is on the 5'-side and T2 which is on the 3'-side of a set of genes). The connectron state of a genome provides information that makes it possible to decide where and how connectrons can be deleted from the native genome or added to the native genome to modify genomic gene expression behavior.

L'invention concerne une structure de connectron d'un génome qui détermine des ensembles de quatre séquences ADN d'une longueur minimum de 15 bases (C1 et C2 étant situés dans la séquence non traduite 3' d'un gène, T1 à l'extrémité 5' et T2 à l'extrémité 3' d'un ensemble de gènes). L'état de connectron d'un génome fournit des informations qui permettent de décider de l'endroit et de la manière dont les connectrons peuvent être supprimés du génome natif ou ajoutés à celui-ci afin de modifier le comportement de l'expression génétique génomique.

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