A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 19/00 (2006.01) A61B 17/00 (2006.01) A61F 2/30 (2006.01) A61L 27/26 (2006.01) A61L 27/34 (2006.01) A61L 27/50 (2006.01) A61B 17/56 (2006.01) A61F 2/00 (2006.01) A61F 2/02 (2006.01)
Patent
CA 2297450
A method for modifying the surface properties of tissue in vivo is described. The method comprises forming a liquid crystalline matrix on the tissue surface wherein the matrix comprises a tissue surface component. In one embodiment there is provided a method for improving the bonding of surgical glues and cements to cartilage and other synovial fluid wetted tissue surfaces. Such surfaces are contacted with a composition comprising a poly(hydroxy substituted amino acid) to form a liquid crystalline matrix on the tissue surface. The matrix is readily removed to provide a tissue surface that exibits improved bonding with surgical glues.
L'invention concerne un procédé pour modifier les caractéristiques de surface de tissus in vivo. Ce procédé consiste à former une matrice cristalline liquide sur la surface tissulaire, cette matrice comportant un constituant de surface tissulaire. Dans un mode de réalisation, on décrit un procédé pour améliorer l'adhérence des colles et ciments chirurgicaux sur le cartilage et d'autres surfaces tissulaires humidifiées par le liquide synovial. Ces surfaces sont mises en contact avec une composition comprenant un aminoacide à substitution poly(hydroxy) pour former une matrice cristalline liquide sur la surface tissulaire. Cette matrice s'élimine aisément pour donner une surface tissulaire présentant une liaison améliorée avec les colles chirurgicales.
Hwang Julia
Stupp Samuel I.
Smart & Biggar
The Board Of Trustees Of The University Of Illinois
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