C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2701639
Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
L'invention vise à moduler sélectivement l'expression génétique dans le génome d'une cellule de mammifère le nécessitant, par détermination de la présence d'un transcrit antisens codé chevauchant un promoteur du gène cible, par mise en contact du transcrit avec un ARNag ou un 'gapmère' complémentaire d'une partie du transcrit en amont du site de début de transcription du gène, et par détection d'une modulation résultante de l'expression du gène cible.
Corey David R.
Janowski Bethany A.
Schwartz Jacob C.
Younger Scott T.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
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