Modulating insulin receptor signaling through targeting facl

Details Modulating insulin receptor signaling through targeting facl Modulating insulin receptor signaling through targeting facl

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12N 9/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2462587

Human FACL genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of FACL, comprising screeing for agents that modulate the activity of FACL are provided.

L'invention concerne des gènes humains de FACL (acyl-CoA synthétase) identifiés comme des modulateurs de la signalisation des récepteurs de l'insuline (INR), constituant ainsi des cibles thérapeutiques contre les troubles liés à une mauvaise signalisation des récepteurs de l'insuline (INR). L'invention concerne également des méthodes d'identification de modulateurs des gènes de FACL, comprenant le criblage d'agents modulant l'activité de FACL.

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