Modulating multiple lineage kinase proteins

Details Modulating multiple lineage kinase proteins Modulating multiple lineage kinase proteins

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A61K 31/40 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2419985

Methods for identifying compounds which modulate activity of a multiple linease kinase protein and promotes cell survival or cell death comprising the steps of contacting the cell containing the multiple linease protein with the compound, determining whether the compound decreases activity of the multiple linease protein, and determining whether the compound promotes cell survival are provided. Methods for identifying compounds which may be useful in the treatment of neurodegenerative disorders and/or inflammation are also provided. Methods for modulating the activity of a multiple linage kinase protein comprising contacting the protein or a cell containing the protein with an indeno- or indolo-compound of the invention are also provided. Methods of treating nuerodegenerative disorders and/or inflammation are also provided

Cette invention a trait à des procédés permettant d'identifier des composés qui modulent l'activité d'une protéine kinase à lignée multiple et favorisent la survie ou la mort de cellules. Ces procédés consistent à mettre en contact la cellule contenant cette protéine avec le composé, à déterminer si ce composé diminue l'activité de celle-ci et s'il favorise la survie des cellules. L'invention concerne également des procédés permettant d'identifier des composés susceptibles d'être utilisés dans le traitement de troubles neurodégénératifs et/ou inflammatoires. Elle porte, en outre, sur des procédés visant à moduler l'activité de cette protéine, lesquels procédés consistent à mettre en contact la protéine ou la cellule contenant la protéine avec un composé indéno ou indolo. Elle concerne également des méthodes de traitement de troubles neurodégénératifs et/ou inflammatoires.

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