Modulating production of pneumococcal capsular polysaccharide

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/02 (2006.01) A01N 63/00 (2006.01) A61K 39/09 (2006.01) A61K 49/00 (2006.01) C12N 1/00 (2006.01) C12N 1/20 (2006.01) C12P 19/04 (2006.01) C12Q 1/04 (2006.01) C12Q 1/18 (2006.01)

Patent

CA 2403001

The invention relates to methods of modulating capsular polysaccharide production in pneumococci such as Streptococcus pneumoniae. The invention further relates to methods of alleviating pneumococcal infections in animals, and to methods of identifying both agents capable of modulating pneumococcal infections in animals. Figure (1) comprising figures 1Ai-1Avi and 1Bi-1Bvi is a series of images indicating the effect of environmental oxygen and carbon dioxide concentration on colony morphology and capsule size, as assessed using the Quellung reaction.

L'invention concerne des procédés servant à moduler la production de polysaccharides capsulaires dans des pneumocoques, tels que Streptococcus pneumoniae. Elle concerne, de plus, des procédés servant à soulager des animaux atteints d'infections par des pneumocoques et des procédés servant à identifier à la fois des agents capables de moduler des infections par pneumocoques chez l'animal. La figure (1) comprenant les figures 1Ai-1Avi et 1Bi-1Bvi illustre une série d'images indiquant l'effet de la concentration d'oxygène et d'oxyde de carbone de l'environnement sur la morphologie de colonies et la dimensions de capsules, comme l'évalue la réaction de Quellung.

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