Modulating ramp activity

Details Modulating ramp activity Modulating ramp activity

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) A61P 9/00 (2006.01) C07K 14/705 (2006.01) C12N 5/06 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/554 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2363951

The invention provides genetically-modified non-human mammals and genetically-modified animal cells containing a disrupted RAMP1, RAMP2, or RAMP3 gene. Also provided by the invention are methods of screening for agents that modulate the activity or expression of a RAMP and methods of treating mammals to modulate liver function and/or muscle metabolism.

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