Modulation of 5-ht2 receptors as a treatment for...

Details Modulation of 5-ht2 receptors as a treatment for... Modulation of 5-ht2 receptors as a treatment for...

A - Human Necessities

61

K

A61K 31/00 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2551553

The present invention provides for methods of treating and preventing muscle atrophy, cardiac hypertrophy, heart failure and/or primary pulmonary hypertension linked to a family of serotonin receptors called 5-HT2 receptors. The present invention further demonstrates that modulators of 5-HT2 receptors can inhibit or treat muscle atrophy, heart failure, cardiac hypertrophy, and/or primary pulmonary hypertension.

La présente invention a trait à des procédés de traitement et de prévention d'atrophie musculaire, d'hypertrophie cardiaque, d'insuffisance cardiaque et/ou d'hypertension pulmonaire primaire liés à la famille des récepteurs de la sérotonine désignés récepteurs 5-HT2. La présente invention a également trait à des modulateurs de récepteurs 5-HT2 aptes à l'inhibition ou au traitement d'atrophie musculaire, d'hypertrophie cardiaque, d'insuffisance cardiaque et/ou d'hypertension pulmonaire primaire.

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