Modulation of a.beta. levels by .beta.-secretase bace2

Details Modulation of a.beta. levels by .beta.-secretase bace2 Modulation of a.beta. levels by .beta.-secretase bace2

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C07K 14/47 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2413209

The present invention is based on the findings that BACE2, a homolog of .beta.- secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A.beta.. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress A.beta. production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.

L'invention est basée sur la découverte que BACE2, une homologue de la .beta.-sécrétase BACE, peut stimuler la transformation d'APP dans une voie non amyloïdogène, supprimant ainsi le niveau A.beta.. La présente invention concerne aussi des procédés et des moyens pour identifier et utiliser des modulateurs de cette activité particulière de BACE2 visant à supprimer la production d'A.beta.. Les composés identifiés grâce à ces procédés et à ces moyens peuvent être utilisés comme candidats potentiels pour le traitement de la maladie d'Alzheimer et d'autres affections neurologiques.

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