Modulation of angiogenesis by a-beta peptide fragments

C - Chemistry – Metallurgy – 07 – K

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C07K 14/47 (2006.01)

Patent

CA 2619455

Provided are A.beta. peptide fragments that are useful in inhibiting angiogenesis. Also provided are methods for the treatment of pathological or unwanted angiogenesis and conditions and diseases associated therewith by administering an effective amount of an A.beta. fragment. In a particular embodiment, the peptide fragment includes the sequence HHQKLVFF.

La présente invention porte sur des fragments de peptide Aß qui sont utiles pour inhiber l'angiogenèse. Cette invention concerne également des méthodes de traitement de l'angiogenèse pathologique ou indésirable ainsi que des pathologies et des maladies associées à cette dernière, lesdites méthodes consistant à administrer une quantité efficace d'un fragment Aß. Dans une forme de réalisation particulière, le fragment de peptide contient la séquence HHQKLVFF.

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