Modulation of animal cellular responses with compositions...

Details Modulation of animal cellular responses with compositions... Modulation of animal cellular responses with compositions...

A - Human Necessities

61

K

167/202

A61K 31/70 (2006.01) C07H 19/16 (2006.01)

Patent

CA 1236401

ABSTRACT Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.

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