Modulation of apolipoprotein c-iii expression

Details Modulation of apolipoprotein c-iii expression Modulation of apolipoprotein c-iii expression

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2522560

Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.

L'invention concerne des composés, des compositions et des méthodes permettant de moduler l'expression d'apolipoprotéine C-III. Lesdites compositions comprennent des oligonucléotides, ciblés sur l'apolipoprotéine C-III codant l'acide nucléique. L'invention concerne également des méthodes faisant appel auxdits composés pour moduler l'expression de l'apolipoprotéine C-III et pour assurer le diagnostic et le traitement d'affections associées à l'expression de l'apolipoprotéine C-III.

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