Modulation of bone formation

Details Modulation of bone formation Modulation of bone formation

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61P 19/08 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2638803

This invention relates to modulating Ror activity (e.g., Ror2 protein activity) and/or 14-3-3 .beta. to affect bone formation or resorption. The invention further relates to compositions and methods for the screening, diagnosis and development of therapies for bone-related disorders such as osteoporosis and bone fracture. Antibodies and antibody fragments directed to Ror2 protein are particularly useful in causing dimerization of Ror2 proteins, thereby leading to the activation of Ror2.

La présente invention concerne une modulation de l'activité Ror (par exemple, l'activité de la protéine Ror2) et/ou de 14-3-3 .beta. permettant d'avoir un effet sur la formation ou la résorption osseuse. L'invention concerne en outre des compositions et des méthodes pour le dépistage, le diagnostic et le développement de thérapies de troubles liés aux os, tels que l'ostéoporose et la fracture d'os. Des anticorps et des fragments d'anticorps dirigés contre une protéine Ror2 sont particulièrement utiles pour causer une dimérisation de protéines Ror2, amenant ainsi une activation de Ror2.

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