Modulation of cartilage homeostasis

Details Modulation of cartilage homeostasis Modulation of cartilage homeostasis

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2564968

The present invention relates to a linear or cyclic peptide and the use of said peptide in medicine and especially in the manufacture of a medicament for the treatment and/or prophylaxis of a disease associated with inflammatory mediated cartilage destruction such as, e.g. an inflammatory joint disease such as, e.g., rheumatoid arthritis, psoriatic arthritis, juvenile chronic arthritis, systemic lupus erythematosus (SLE), infectious arthritis and juvenile idiopathic arthritis, other diseases involving joint structures such as, e.g., osteoarthritis, meniscal damage, gout, diseases affecting structural elements of the musculoskeletal system such as, e.g., tendon damage, ligament damage and bone disease such as, e.g., osteoporosis, diseases affecting major arteries including atherosclerosis. The minimal core sequence of the linear or cyclic peptide according to the invention is [WKY]-[LR]-[ES]-[AKDE]-K, comprising peptides such as, e.g., WLEAK, LRRWLEAK, QLRGLRRWLEAK, QLRGLRRWLEAKAS, CQLRGLRRWLEAKASRPDATC, CQLRGLRRWLEAKC, CWLEAKC, KRSKK, CKRSKKC, KFPTKRSKKAGRH and CKFPTKRSKKAGRH.

La présente invention concerne un peptide linéaire ou cyclique et l'utilisation dudit peptide en médecine et plus particulièrement dans la fabrication d'un médicament destiné au traitement et/ou à la prophylaxie d'une maladie associée à la destruction du cartilage à médiation inflammatoire telle que, par exemple, une maladie articulaire inflammatoire comme par exemple la polyarthrite rhumatoïde, la polyarthrite psoriasique, l'arthrite chronique juvénile, le lupus érythémateux disséminé, l'arthrite infectieuse et l'arthrite idiopathique juvénile, d'autres maladies impliquant des structures articulaires telles que par exemple l'arthrose, les lésions du ménisque, la goutte, les maladies affectant des éléments d'ossature du système musculo-squelettique comme par exemple les lésions tendineuses, les atteintes ligamentaires et les maladies osseuses telles que par exemple l'ostéoporose, les maladies affectant les artères principales y compris l'athérosclérose. La séquence noyau minimale du peptide linéaire ou cyclique selon l'invention est [WKY]-[LR]-[ES]-[AKDE]-K, et comprend les peptides tels que, par exemple, WLEAK, LRRWLEAK, QLRGLRRWLEAK, QLRGLRRWLEAKAS, CQLRGLRRWLEAKASRPDATC, CQLRGLRRWLEAKC, CWLEAKC, KRSKK, CKRSKKC, KFPTKRSKKAGRH et CKFPTKRSKKAGRH.

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