Modulation of cellular response to external stimuli

Details Modulation of cellular response to external stimuli Modulation of cellular response to external stimuli

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A61K 31/47 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) C12Q 1/02 (2006.01) C12Q 1/42 (2006.01)

Patent

CA 2109796

Compounds of formula (I), wherein one and only one of R1 and R3 is a straight- chain or branched-chain .omega.- or (.omega.-1)- hydroxyalkyl (5-8C), or is an (.omega.-1)-oxoalkyl (5-8C) or is an (.omega., .omega.-1) or (.omega.- 1, .omega.-2) -dihydroxyalkyl (5-8C), or is an alkenyl substituent (5-8C), and the other is alkyl (1-12C) optionally containing one or two non-adjacent oxygen atoms in place of C, and wherein R2 is alkyl (1-12C) optionally containing one or two non-adjacent oxygen atoms in place of C, are useful in modulating the effects of internal and external stimuli on cells by reversing the effects of these stimuli on the short-term secondary messenger pathways. In particular, the compounds of Formula (I), lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with said cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.

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