Modulation of chemosensory receptors and ligands associated...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 285/16 (2006.01) A61K 31/395 (2006.01) C07D 239/70 (2006.01) C07D 239/95 (2006.01) C07D 417/10 (2006.01) C07D 417/12 (2006.01) C07D 475/06 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 495/14 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 513/14 (2006.01) C07H 17/00 (2006.01) C40B 30/02 (2006.01) C40B 30/04 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2687453

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

L'invention concerne des procédés d'identification de modificateurs de récepteurs chimiosensoriels et de leurs ligands permettent de déterminer si une entité d'essai est appropriée pour interagir avec un ou plusieurs sites d'interaction dans les domaines des attrape-mouche des récepteurs chimiosensoriels ainsi que des modificateurs pouvant moduler les récepteurs chimiosensoriels et leurs ligands. L'invention concerne également des modificateurs de récepteurs chimiosensoriels et de leurs ligands de formule (I), leurs sous-gènes et des composés spécifiques. En outre, l'invention comprend des compositions à ingérer incluant les modificateurs de récepteurs chimiosensoriels et leurs ligands ainsi que des procédés d'utilisation des modificateurs de récepteurs chimiosensoriels et de leurs ligands pour améliorer le goût sucré d'une composition à ingérer ou traiter une affection associée à un récepteur chimiosensoriel. De plus, l'invention comprend des procédés de préparation des modificateurs de récepteurs chimiosensoriels et de leurs ligands.

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