Modulation of cytokine signaling regulators and applications...

Details Modulation of cytokine signaling regulators and applications... Modulation of cytokine signaling regulators and applications...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2574572

The present invention relates to regulation of antigen presentation by cytokine signaling regulators in antigen presenting cells, such as dendritic cells. The invention provides methods of modulating antigen presentation through modulation of cytokine signaling regulators, such as SOCS (SOCS 1-7, CIS), SHP (SHP-1 and SHP-2) or PIAS (PIAS1, PIAS3, PIASx and PIASy). The present invention provides vaccines and therapies in which antigen presentation is enhanced through modulation of cytokine signaling regulators. The present invention also provides a mechanism to break self tolerance in tumor vaccination methods that rely on presentation of self tumor antigens.

La présente invention se rapporte à la régulation de la présentation de l'antigène par des régulateurs de la signalisation des cytokines dans les cellules présentatrices d'antigène telles que les cellules dendritiques. L'invention concerne des méthodes permettant de moduler la présentation de l'antigène par la modulation de régulateurs de la signalisation des cytokines tels que SOCS (SOCS 1-7, CIS), SHP (SHP-1 et SHP-2) ou PIAS (PIAS1, PIAS3, PIASx et PIASy). L'invention concerne également des vaccins et des traitements dans lesquels la présentation de l'antigène est améliorée par modulation des régulateurs de signalisation des cytokines. L'invention porte en outre sur un mécanisme permettant de lever la tolérance au soi dans les méthodes de vaccination antitumorale fondées sur la présentation des antigènes tumoraux du soi.

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