C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 9/99 (2006.01)
Patent
CA 2612640
The present invention relates generally to a method of modulating EGFR- mediated cellular functional activity and agents useful for same. More particularly, the present invention relates to a method of modulating agonist induced EGFR-mediated cellular proliferation by modulating upstream intracellular sphingosine kinase signalling. The method of the invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant EGFR-mediated cellular functioning, in particular aberrant EGFR-mediated cellular proliferation.
La présente invention concerne généralement un procédé de modulation d~activité fonctionnelle cellulaire induite par l~EGFR et les agents utiles pour ce faire. Plus particulièrement, la présente invention concerne un procédé de modulation d~antagoniste induit par la prolifération cellulaire induite par l~EGFR en modulant en amont la signalisation de sphingosine kinase intracellulaire. Le procédé de l~invention s~avère utile, entre autres, dans le traitement et/ou la prophylaxie des états caractérisés par le fonctionnement cellulaire induit par l~EGFR, en particulier une prolifération cellulaire aberrante induite par l~EGFR.
Sukocheva Olga
Vadas Mathew Alexander
Xia Pu
Fetherstonhaugh & Co.
Medvet Science Pty. Ltd.
Sukocheva Olga
Vadas Mathew Alexander
Xia Pu
LandOfFree
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