Modulation of enos activity and therapeutic uses thereof

Details Modulation of enos activity and therapeutic uses thereof Modulation of enos activity and therapeutic uses thereof

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2385665

The present invention provides uses of VEGF or VEGF receptor agonists for the up-regulation of eNOS expression and activity. VEGF and VEGF receptor agonists are useful in the treatment of or prevention from hypertension, diabetes, angina, thrombosis, atherosclerosis, heart failure, and other conditions or disorders wherein nitric oxide is an important regulator.

La présente invention concerne l'utilisation de VEGF (vascular endothelial growth factor / facteur de croissance endothéliale vasculaire) ou d'agonistes de récepteurs VEGF pour la régulation vers le haut de l'expression et de l'activité de l'eNOS (endothelial nitric oxide synthase / synthase endothéliale de l'oxyde nitrique). Le VEGF et les agonistes de récepteurs VEGF peuvent être utilisés pour le traitement ou la prévention de l'hypertension, des diabètes, de l'angine, de la thrombose, de l'athérosclérose, de l'insuffisance cardiaque, et d'autres états pathologiques ou troubles dans lesquels l'oxyde nitrique est un important régulateur.

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