Modulation of factor 7 expression

Details Modulation of factor 7 expression Modulation of factor 7 expression

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) C07H 21/00 (2006.01) A61P 7/02 (2006.01) A61P 9/14 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2705316

Disclosed herein are antisense compounds and methods for decreasing Factor 7 and treating or preventing thromboembolic complications, hyperproliferative disorders, or inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 7 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, cancer, rheumatoid arthritis, and fibrosis.

L'invention concerne des composés antisens et des méthodes pour réduire l'expression du facteur 7 et traiter ou prévenir des complications thrombo-emboliques, des troubles hyperprolifératifs ou des états inflammatoires chez un individu nécessitant un tel traitement. Des exemples d'états pathologiques pouvant être atténués par administration de composés antisens ciblés sur le facteur 7 incluent la thrombose, l'embolie et la thrombo-embolie, et notamment la thrombose veineuse profonde, l'embolie pulmonaire, l'infarctus du myocarde, l'accident vasculaire cérébral, le cancer, l'arthrite rhumatoïde et la fibrose.

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