A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7125 (2006.01) A61K 31/513 (2006.01) A61K 31/7068 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2347003
The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same. In addition, the invention relates to the modulation of mammalian gene expression regulated by methylation.
Cette invention concerne la modulation de l'expression génétique. Elle s'applique plus particulièrement à des compositions renfermant des oligonucléotides antisens qui inhibent l'expression d'un gène associé fonctionnellement avec les protéines effectrices d'un produit de ce gène, ainsi qu'à des méthodes d'utilisation de ces compositions. De plus, l'invention concerne la modulation de l'expression d'un gène de mammifère régulée par méthylation.
Besterman Jeffrey M.
Li Zuomei
Macleod Alan R.
Siders William M.
Methylgene Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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