Modulation of glucose-6-phosphatase translocase expression

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07H 21/04 (2006.01) C12N 15/12 (2006.01) C12N 15/55 (2006.01)

Patent

CA 2563801

Compositions and methods are provided for decreasing blood glucose levels in an animal, comprising administering to said animal an antisense inhibitor of glucose-6-phosphatase translocase expression alone or in combination with at least one glucose-lowering drug. Also provided are compositions and methods for treating diabetes and other metabolic disorders.

Des compositions et des procédés sont proposes pour réduire les taux de glycémie chez un animal, comprenant l~administration au dit animal d~un inhibiteur antisens de l~expression de la glucose-6-phosphatase translocase seul ou en combinaison avec au moins un médicament de réduction de la glycémie. Sont également proposés des compositions et des procédés de traitement des diabètes et d~autres affections métaboliques.

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