Modulation of granulosa cell apoptosis

Details Modulation of granulosa cell apoptosis Modulation of granulosa cell apoptosis

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 8/00 (2006.01) A61K 38/22 (2006.01) A61P 15/08 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2615006

The present invention relates to a method of modulating apoptosis of a granulosa cell. The method includes one or more of the following steps: (i) modulating the concentration and/or activity of BMP-15 and/or BMP-6 that the granulosa cell is exposed to; (ii) modulating activity of a BMP-15 dependent signalling pathway in the granulosa cell; and (iii) modulating activity of a BMP-6 dependent signalling pathway in a granulosa cell.

L'invention concerne un procédé de modulation de l'apoptose d'une cellule de la granulosa. Le procédé comprend une ou plusieurs étapes suivantes consistant: (i) à moduler la concentration et/ou l'activité de BMP-15 et/ou BMP-6 auxquelles la cellule de la granulosa est exposée; (ii) à moduler l'activité d'une voie de signalisation dépendante de BMP-15 dans la cellule de la granulosa; et (iii) à moduler l'activité d'une voie de signalisation dépendante de BMP-6 dans une cellule de la granulosa.

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