Modulation of growth hormone receptor expression and...

Details Modulation of growth hormone receptor expression and... Modulation of growth hormone receptor expression and...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2517101

Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.

L'invention concerne des composés, des compositions et des méthodes destinés à moduler l'expression du récepteur de l'hormone de croissance et/ou du facteur de croissance insulinoïde I (IGF-I). Les compositions de l'invention comprennent des oligonucléotides dirigés contre l'acide nucléique codant le récepteur de l'hormone de croissance. L'invention concerne également des méthodes d'utilisation de ces composés pour moduler l'expression du récepteur de l'hormone de croissance et pour diagnostiquer et traiter une maladie associée à l'expression du récepteur de l'hormone de croissance et/ou du facteur de croissance insulinoïde I. L'invention concerne en outre des méthodes et des trousses de diagnostic.

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