Modulation of homologous recombination with single stranded...

Details Modulation of homologous recombination with single stranded... Modulation of homologous recombination with single stranded...

C - Chemistry, Metallurgy

12

N

C12N 15/90 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2422175

In one aspect of the invention, single stranded DNA binding proteins (SSB) may be used to modulate homologous recombination in mitosis or meiosis. Methods are provided for modulating homologous recombination comprising transforming a cell with a nucleic acid encoding a single stranded DNA binding protein; and, allowing the cell to undergo mitosis or meiosis. Similarly, methods are provided for modulating homologous recombination comprising transforming a cell with an inhibitor of expression of a single stranded DNA binding protein, such as an antisense or co-suppressive nucleic acid; and, allowing the cell to undergo mitosis or meiosis.

L'invention porte selon un premier aspect sur des protéines de fixation d'ADN monobrin (SSB) servant à moduler la recombinaison d'homologues dans les mitoses et les méioses. Elle porte en outre sur des procédés de modulation de la recombinaison d'homologues consistant à transformer une cellule par un acide nucléique codant pour une protéine de fixation à un ADN monobrin puis à lui faire subir une mitose ou une méiose, et de façon similaire, sur des procédés de modulation de la recombinaison d'homologues consistant à transformer une cellule par inhibiteur de l'expression d'une protéine de fixation à un ADN monobrin telle qu'un acide nucléique antisens ou co-suppresseur, puis à lui faire subir une mitose ou une méiose.

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