Modulation of homologous recombination with single stranded...

Details Modulation of homologous recombination with single stranded... Modulation of homologous recombination with single stranded...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/245 (2006.01) C12N 15/90 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2318517

In one aspect of the invention, single stranded DNA, binding proteins (SSB) may be used to modulate homologous recombination in mitosis or meiosis. Methods are provided for modulating homologous recombination comprising transforming a cell with a nucleic acid encoding a single stranded DNA binding protein; and, allowing the cell to undergo mitosis or meiosis. Similarly, methods are provided for modulating homologous recombination comprising transforming a cell with an inhibitor of expression of a single stranded DNA binding protein, such as an antisense or co-suppressive nucleic acid; and, allowing the cell to undergo mitosis or meiosis. 19

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