Modulation of immune response by ribavirin

Details Modulation of immune response by ribavirin Modulation of immune response by ribavirin

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/00 (2006.01) C07H 19/052 (2006.01)

Patent

CA 2357735

The response of an immune system to a challenge is modified by presenting the system with a nucleoside in a concentration selected to have an effect on a B7 marker that is inverse from the effect of the challenge. Contemplated challenges include allergens, neoplasm, virus, bacteria, infestation, and autoimmune reaction. Molecular markers of particular interest are B7-1 and B7- 2. Preferred nucleosides are Ribavirin and Ribavirin analogs, especially provided within a concentration range between about 0.2 :M and about 5 :M, respectively, in a fluid containing cells expressing the B7 marker.

La réponse d'un système immunitaire face à un test de provocation est modifiée par un nucléoside dont la concentration est sélectionnée de manière à avoir un effet sur le marqueur B7 inverse à l'effet du test de provocation. Les tests de provocation en question comprennent des allergènes, un néoplasme, un virus, des bactéries, une infestation et une réaction auto-immune. Les marqueurs moléculaires d'intérêt sont les B7-1 et B7-2. Les nucléosides sont de préférence la Ribavirine des analogues de la Ribavirine, présentant surtout une concentration comprise entre environ 0,2 :M et environ 5 :M, dans des cellules contenant un liquide exprimant le marqueur B7.

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