Modulation of immune responses by administration of...

Details Modulation of immune responses by administration of... Modulation of immune responses by administration of...

C - Chemistry, Metallurgy

07

D

C07D 407/12 (2006.01) A61K 31/70 (2006.01) A61P 31/08 (2006.01) C07H 17/08 (2006.01)

Patent

CA 2733706

Provided are compounds of formula (III) useful for modulation of immune responses, compositions comprising the compounds, and methods of use of such compositions for treating diseases or disorders involving an immune response. In certain embodiments, the compounds are useful for the treatment of diseases or disorders associated with transendothelial migration of T cells and activated T cells, and proinflammatory cytokine production from T cells and macrophages. Diseases or disorders that can be treated include arthritic and rheumatic disorders, such as rheumatoid arthritis.

La présente invention concerne des composés utiles dans la modulation de réponses immunes, des compositions comprenant lesdits composés, et des procédés d'utilisation de ces compositions dans le traitement de maladies ou de troubles impliquant une réponse immune. Dans certains modes de réalisation, ces composés sont utiles dans le traitement de maladies ou de troubles associés à la migration transendothéliale des cellules T et des cellules T activées, et à la production de cytokine proinflammatoire à partir de cellules T et de macrophages. Les maladies ou les troubles qui peuvent être traités incluent les troubles arthritiques et rhumatiques, tels que l'arthrite rhumatoïde.

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