C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2512484
The Invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a Patient in need of immunostimulation. The immunomers and an immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3' ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5' end.
L'invention porte sur l'utilisation à des fins thérapeutiques d'oligonucléotides servant d'agents immunostimulants dans des applications immunothérapeutiques, et plus particulièrement sur des immunomères et des oligonucléotides immunostimulants utilisables dans des méthodes d'élaboration d'une réponse immunitaire ou de traitement de patients nécessitant une immunostimulation. Les immunomères et les oligonucléotides immunostimulants de l'invention, qui consistent de préférence en nouvelles purines, comportent au moins deux oligonucléotides fixés par leurs extrémités 3', par leurs liaisons internucléoside ou par leur nucléobase ou sucre fonctionnalisés, à un liant non nucléotidique, l'un des oligonucléotides étant immunomodulatoire et présentant une extrémité 5' accessible.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar
Yu Dong
Hybridon Inc.
Idera Pharmaceuticals Inc.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
LandOfFree
Modulation of immunostimulatory properties of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulation of immunostimulatory properties of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of immunostimulatory properties of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1519984