Modulation of immunostimulatory properties of...

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A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2463798

The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3' ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5' end.

La présente invention se rapporte à l'utilisation thérapeutique d'oligonucléotides en tant qu'agents immunostimulants dans des applications d'immunothérapie. De manière plus spécifique, cette invention concerne des immunomonomères destinés à être utilisés dans des méthodes permettant de générer une réponse immunitaire ou de traiter un patient nécessitant une immunostimulation. Les immunomonomères selon l'invention comprennent au moins deux oligonucléotides liés au niveau de leurs extrémités 3', des liaisons internucléoside ou d'une nucléobase fonctionnalisée ou d'un sucre lié par un agent de liaison non nucléotidique, au moins un des oligonucléotides étant un oligonucléotide immunostimulant et comportant une extrémité 5' accessible.

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