C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/52 (2006.01) A61K 38/19 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2316405
The invention provides methods of inhibiting the biological activity or the in vivo biological activity of CC-chemokines (including native MCP-3), such as methods of inhibiting inflammation, comprising administering to a host an effective amount of a CC-chemokine receptor antagonist of the present invention. In same embodiments, the invention may provide methods of modulating an immune response in a host, or treating inflammation or autoimmune disease in a host suffering from such diseases, comprising administering to the host an effective amount of a CC-chemokine receptor antagonist of the present invention. Another aspect of the present invention is directed to pharmaceutical compositions comprising an antagonistically effective amount of a CC-chemokine receptor antagonist of the present invention and a pharmaceutically ecceptable carrier. In alternative aspects, the invention provides compounds and methods for cancer treatment that facilitate an affective immune response.
Clark-Lewis Ian
Gong Jiang-Hong
Mcquibban G. Angus
Overall Christopher Mark
Clark-Lewis Ian
Gong Jiang-Hong
Mcquibban G. Angus
Overall Christopher Mark
Smart & Biggar
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