A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2307705
The invention provides methods of inhibiting the biological activity or the in vivo biological activity of CC-chemokines, including native MCP-3, comprising administering to a host, e.g., mammal (for example, human) a therapeutically effective amount of a CC-chemokine receptor antagonist of the present invention, for a time and under conditions sufficient to inhibit the biological activity of the native molecules. In some embodiments, the invention may provide methods of modulating an immune response in a host, or treating inflammatory or autoimmune diseases in a host suffering from such diseases, comprising administering to the host, such as a mammal, a therapeutically effective amount of a CC-chemokine receptor antagonist of the present invention. Another aspect of the present invention is directed to pharmaceutical compositions comprising an antagonistically effective amount of a CC-chemokine receptor antagonist of the present invention and a pharmaceutically acceptable carrier.
Clark-Lewis Ian
Gong Jiang-Hong
Mcquibban G. Angus
Overall Christopher Mark
Clark-Lewis Ian
Gong Jiang-Hong
Mcquibban G. Angus
Overall Christopher Mark
Smart & Biggar
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