Modulation of insulin like growth factor i receptor expression

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 45/00 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2515484

The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.

La présente invention porte sur des compositions et sur des procédés visant à moduler l'expression du gène du facteur de croissance. L'invention porte notamment sur des composés, en particulier des composés oligonucléotides qui, selon des formes d'exécution préférées, s'hybrident aux molécules d'acide nucléique codant le récepteur du facteur de croissance 1 analogue à l'insuline (récepteur d'IGF-I ou IGF-IR) et en particulier le récepteur humain IGF-IR. Ces composés sont ici pris comme exemple pour moduler la prolifération qui est liée au traitement des maladies de la peau prolifératives et inflammatoires et au traitement du cancer. Et il est bien entendu qu'ils peuvent être utilisés pour tout autre état, y compris des états inflammatoires, où est impliqué IGF-IR.

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