Modulation of integrin-mediated signal transduction

Details Modulation of integrin-mediated signal transduction Modulation of integrin-mediated signal transduction

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/17 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2207973

The present invention discloses that phosphorylation of cytoplasmic tyrosine residues in the .beta.-subunit of integrins is needed for signal protein association. The invention provides methods of identifying signaling partners involved in integrin mediated signaling, methods of identifying agents which block integrin mediated signaling, methods of using agents which block intergrin mediated signaling to modulate biological and pathological processes, and agents which block integrin mediated signaling.

L'invention révèle que la phosphorilation de restes de tyrosine cytoplasmique dans les sous-unités .beta. d'intégrines est nécessaire à l'association de protéines de signal. L'invention présente des procédés d'identification de partenaires de signalisation impliqués dans la signalisation induite par des intégrines, des procédés d'identification d'agents bloquant la signalisation induite par des intégrines, des procédés d'utilisation d'agent bloquant la signalisation induite par des intégrines pour moduler les processus biologique et pathologique, ainsi que des agents bloquant la signalisation induite par des intégrines.

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