Modulation of matrix metalloproteinase (mmp) activity with...

Details Modulation of matrix metalloproteinase (mmp) activity with... Modulation of matrix metalloproteinase (mmp) activity with...

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 31/585 (2006.01)

Patent

CA 2495376

The present invention is directed to a method for preventing an increase in matrix metalloproteinase (MMP) activity or reducing MMP activity in a subject in need thereof by administering to the subject a therapeutically effective amount of a selective aldosterone blocker. More particularly, the present invention is directed to attenuating or preventing an increase in MMP activity comprising administering eplerenone, or derivatives thereof.

L'invention concerne un procédé permettant d'empêcher une augmentation de l'activité de la métalloprotéinase matricielle (MMP) ou de réduire une telle activité chez un patient qui en a besoin par administration audit patient d'une dose thérapeutiquement efficace d'un anti-aldostérone sélectif. Plus précisément, l'invention concerne l'atténuation ou la prévention d'une augmentation de l'activité de MMP consistant à administrer l'éplérénone ou des dérivés de celui-ci.

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