Modulation of meiotic recombination

Details Modulation of meiotic recombination Modulation of meiotic recombination

C - Chemistry, Metallurgy

12

N

C12N 15/01 (2006.01) A01H 1/02 (2006.01) A01K 67/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2422362

The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to modify the frequency of meiotic homologous recombination involving the exchange of genetic information between non-sister chromatids from homologous maternal and paternal chromosomes. The steps at which modulation may occur include: homologous chromosome pairing, double-strand break formation; resection; strand invasion; branch migration; and resolution. Methods of plant and animal breeding are also provided that utilize the modulation of meiotic homologous recombination.

Cette invention a trait à des procédés permettant de modifier le niveau d'expression ou l'activité fonctionnelle de certains facteurs, notamment des enzymes ou d'autres protéines catalytiques ou encore des protéines de structure, seules ou conjointes et ce, afin de modifier la fréquence d'une recombinaison méiotique homologue impliquant l'échange d'une information génétique entre des chromatides non soeurs issues de chromosomes homologues, maternels et paternels. Parmi les phases pendant lesquelles la modulation est susceptible de se produire figurent, l'appariement des chromosomes homologues, la formation d'une cassure bicaténaire, la résection, l'invasion de brins, la migration de ramifications et la résolution. L'invention porte également sur des techniques de reproduction de plantes et d'animaux faisant intervenir la modulation de la recombinaison méiotique homologue.

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