C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 45/06 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2733059
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of MyD88. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding MyD88. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding MyD 88 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating MyD88 expression and for prevention or treatment of diseases wherein modulation of MyD 88 expression would be beneficial are provided.
La présente invention concerne des composés oligonucléotides antisens, compositions et procédés pour réguler à la baisse lexpression de MyD88. Les compositions comprennent des oligonucléotides antisens ciblés vers des acides nucléiques codant pour MyD88. Les compositions peuvent comprendre en outre des oligonucléotides antisens ciblés vers des acides nucléiques codant pour MyD88 en combinaison avec dautres composés et/ou compositions thérapeutiques et/ou prophylactiques. La présente invention concerne en outre des procédés dutilisation de ces composés et compositions pour réguler à la baisse lexpression de MyD88 et pour la prévention ou le traitement de maladies dans lesquelles la modulation de lexpression de MyD 88 serait bénéfique.
Agrawal Sudhir
Bhagat Lakshimi
Kandimalla Ekambar R.
Putta Mallikarjuna
Wang Daqing
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Idera Pharmaceuticals Inc.
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