A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2613166
The invention includes compositions and methods for enhancing immunopotency of an immune cell by way of inhibiting a negative immune regulator in the cell. The present invention provides vaccines and therapies in which antigen presentation is enhanced through inhibition of negative immune regulators. The present invention also provides a mechanism to break self tolerance in tumor vaccination methods that rely on presentation of self tumor antigens.
Compositions et procédés permettant d'augmenter l'immuno-activité d'une cellule immune par inhibition de régulateur immune négatif dans la cellule. Vaccins et thérapies dans lesquels la présentation d'antigène est augmentée par inhibition de régulateurs immunes négatifs. Enfin, mécanisme éliminant la tolérance au soi dans les procédés de vaccination antitumeur qui reposent sur la présentation d'autoantigènes spécifiques à la tumeur.
Chen Si-Yi
Evel-Kabler Kevin C.
Huang Xue F.
Sharabi Andrew
Song Xiaotong
Baylor College Of Medicine
Chen Si-Yi
Evel-Kabler Kevin C.
Gowling Lafleur Henderson Llp
Huang Xue F.
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