Modulation of nitric oxide production

Details Modulation of nitric oxide production Modulation of nitric oxide production

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/30 (2006.01)

Patent

CA 2304719

A method of treating cells that carry at least one APOE4 allele comprises increasing nitric oxide levels in the cells (e.g., by administering an exogenous source of nitric oxide to the cells) by an amount sufficient to combat the decrease of nitric oxide level associated with the presence of the APOE4 allele. Also disclosed is a method of increasing nitric oxide levels in cells in need thereof which comprises administering APOE to the cells in an amount sufficient to increase nitric oxide levels in the cells.

L'invention concerne un procédé servant à traiter des cellules qui portent au moins un allèle APOE4, ce procédé comportant l'étape consistant à accroître les taux d'oxyde nitrique dans les cellules (p. ex. par l'apport d'une source exogène d'oxyde nitrique aux cellules) selon une quantité suffisante pour combattre une diminution du taux d'oxyde nitrique associée à la présence de l'allèle APOE4. L'invention concerne également un procédé servant à accroître les taux d'oxyde nitrique dans des cellules nécessitant un tel traitement, qui comporte l'étape consistant à administrer aux cellules de l'APOE en quantité suffisante pour accroître les taux d'oxyde nitrique dans ces cellules.

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