A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 45/00 (2006.01) A61P 37/00 (2006.01) C07K 4/00 (2006.01) C07H 15/06 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01)
Patent
CA 2678618
The invention is directed to methods of modulating an immune response in an animal, comprising administering a composition comprising one or more soluble CDId complexes, in particular non-specific soluble CDId complexes. Soluble CDId complexes comprise a soluble CDId polypeptide, a .beta.2-microglobulin polypeptide, and a ceramide-like glycolipid antigen bound to the CDId antigen binding groove, and in certain embodiments, an immunogen. The administration of compositions of the present invention affects the activity of CD Id-restricted NKT cells, and in particular, allows for multiple administrations without causing CD Id-restricted NKT cell anergy.
L'invention concerne des procédés pour moduler une réponse immune chez un animal. Lesdits procédés comportent l'administration d'une composition incluant un ou plusieurs complexes CDId solubles, en particulier des complexes CDId solubles non-spécifiques. Lesdits complexes CDId solubles comprennent un polypeptide CDId soluble, un polypeptide .beta.2-microglobuline et un antigène glycolipidique analogue à de la céramide lié à la rainure de liaison d'antigène CDId ainsi que, dans certains modes de réalisation, un immunogène. L'administration de compositions de la présente invention affecte l'activité des cellules MKT limitées en CDId, et permet, en particulier, des administrations multiples sans provoquer une anergie de cellules NKT limitées en CDId.
Donda Alena
Mach Jean-Pierre
Stirnemann Kathrin
Mbm Intellectual Property Law Llp
Vaccinex Inc.
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