Modulation of osteoblast activity by fhl2

Details Modulation of osteoblast activity by fhl2 Modulation of osteoblast activity by fhl2

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2530130

The invention relates to the use of an Fhl2 nucleic acid for the manufacture of a medicament for the treatment of bone diseases such as osteoporosis. The invention further provides a method for diagnosing a bone disease comprising measuring the level of expression of the Fhl2 gene. The invention also provides the use of a non-human mammal characterized by a decreased level of expression of the Fhl2 gene as an osteoporosis model.

L'invention concerne l'utilisation d'un acide nucléique de Fhl2 pour la production d'un médicament servant au traitement de maladies osseuses, telles que l'ostéoporose. L'invention concerne en outre un procédé pour diagnostiquer une maladie osseuse, consistant à mesurer le niveau d'expression du gène de Fhl2. Elle concerne également l'utilisation d'un mammifère non humain caractérisé par un niveau d'expression amoindri du gène de Fhl2, comme modèle d'ostéoporose.

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