Modulation of ovulation

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01) A61P 15/08 (2006.01) C07K 14/475 (2006.01) C07K 14/495 (2006.01) C07K 16/22 (2006.01)

Patent

CA 2589898

The present invention is directed to the identification of a novel domain of functional significance on the GDF-9 and GDF-9B molecules and to peptides and antibodies which interact with the domain to modulate the biological activity of these molecules to alter mammalian ovarian function and ovulation rate.

L'invention concerne l'identification d'un nouveau domaine des molécules GDF-9 et GDF-9B, important du point de vue fonctionnel, et les peptides et anticorps qui interagissent avec ce domaine pour moduler l'activité biologique de ces molécules en vue d'une modification de la fonction ovarienne et de la fréquence d'ovulation chez un mammifère.

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