Modulation of pd-1 interactions with its ligands

Details Modulation of pd-1 interactions with its ligands Modulation of pd-1 interactions with its ligands

A - Human Necessities

61

K

A61K 38/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2442182

Disclosed are methods for downmodulating an immune response comprising contacting an immune cell with an agent that modulates the interaction between PD-1 and a PD-1 (e.g., soluble forms of PD-1 or PD-1 ligand or antibodies to PD-1) to thereby modulate the immune response.

L'invention concerne des procédés de modulation restrictive de réponse immunitaire, qui consistent à mettre en contact une cellule immunitaire avec un agent modulant l'interaction entre le récepteur PD-1 et un ligand de ce récepteur PD-1 (par exemple, formes solubles du PD-1 ou de ligand du PD-1, ou anticorps vis-à-vis du PD-1), permettant de moduler la réponse immunitaire.

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