Modulation of pde11a activity

Details Modulation of pde11a activity Modulation of pde11a activity

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01K 67/00 (2006.01) A61K 31/4985 (2006.01) A61K 31/517 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12N 15/85 (2006.01) C12Q 1/44 (2006.01)

Patent

CA 2360485

The invention provides genetically-modified non-human mammals and genetically-modified animal cells containing a functionally disrupted PDE11A gene. Also provided by the invention are methods of screening for agents that modulate PDE11A to modulate spermatogenesis, methods of treating mammals to modulate spermatogenesis, and methods of modulating cAMP and cGMP signal transduction in cells that express PDE11A.

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