Modulation of physiological processes and agents useful for...

A - Human Necessities – 61 – K

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A61K 38/06 (2006.01) A61K 31/198 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2461703

The present invention relates generally to a method of modulating glutathione metabolism in the central nervous system of mammals and to agents for use therein. More particularly, the present invention relates to a method of up- regulating glutathione metabolism in the central nervous system by up- regulating levels of glutathione precursor molecules. The method of the present invention is particularly useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate central nervous system oxidation homeostasis including, but not limited to, schizophrenia.

L'invention concerne généralement un procédé de modulation du métabolisme du glutathion dans le système nerveux central chez les mammifères, et les agents utiles à cet effet. Plus particulièrement, l'invention concerne un procédé de régulation à la hausse du métabolisme du glutathion dans le système nerveux central par une régulation à la hausse des niveaux de molécules précurseurs du glutathion. Ledit procédé est particulièrement utile, inter alia, à des fins de traitement et/ou de prophylaxie d'états caractérisés par une homéostasie d'oxydation du système nerveux central aberrante, non désirée ou inappropriée comprenant, entre autres, la schizophrénie.

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