C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/42 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 16/40 (2006.01) C12N 1/20 (2006.01) C12N 9/12 (2006.01) C12N 9/16 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2401633
The mechanism by which pleiotrophin binds to the receptor protein tyrosine phosphatase .beta./.zeta. (RPTP .beta./.zeta.) is disclosed along with methods of modulating both pleiotrophin expression and signaling to treat, prevent and inhibit abnormal cell growth states. Specifically provided are methods of inhibiting tumor growth, promotion, metastasis, invasiveness and angiogenesis as well as methods of preventing or inhibiting cell adhesion.
L'invention concerne le mécanisme par le biais duquel la pléiotrophine se lie à la protéine tyrosine phosphatase .beta./.zeta. (RPTP .beta./.zeta.) de récepteur, ainsi que des méthodes de modulation de l'expression et la signalisation de la pléiotrophine en vue de traiter, prévenir et inhiber des états de croissance cellulaire anormaux. Notamment, cette invention concerne des méthodes d'inhibition de la croissance tumorale, de la promotion du cancer, de la métastase, du pouvoir envahissant et de l'angiogenèse, ainsi que des méthodes de prévention et d'inhibition de l'adhérence cellulaire.
Barnes-Jewish Hospital
Smart & Biggar
LandOfFree
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