Modulation of prostaglandin/cyclooxygenase metabolic pathways

Details Modulation of prostaglandin/cyclooxygenase metabolic pathways Modulation of prostaglandin/cyclooxygenase metabolic pathways

A - Human Necessities

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A61K 31/403 (2006.01) A61K 31/407 (2006.01) A61K 31/437 (2006.01) A61K 31/566 (2006.01) A61K 31/568 (2006.01) A61K 31/5685 (2006.01) A61K 31/57 (2006.01) A61P 1/00 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 11/06 (2006.01) A61P 17/02 (2006.01) A61P 25/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2670957

A variety of diseases and disorders associated with the metabolic pathways involved in the activities of cyclooxygenase and the synthesis of prostaglandins, for example type 2 diabetes mellitus and its sequelae, ischemic vascular diseases, pain associated with inflammation, inflammatory skin conditions, spinal cord injury, peripheral neuropathy, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis, as well as various types of cancer may be treated or prevented by the use of an agent which selectively enhances production of 15-deoxy-prostaglandin J2. The compounds are 7-hydroxy-steroids or condensed indoles.

Une variété de maladies et troubles associés aux voies métaboliques impliquées dans les activités de la cyclooxygénase et la synthèse de prostaglandines, par exemple le diabète mellitus de type 2 et ses séquelles, les maladies vasculaires ischémiques, la douleur associée à l'inflammation, les conditions inflammatoires cutanées, la blessure médullaire, la neuropathie périphérale, la sclérose en plaques, l'affection abdominale inflammatoire et la polyarthrite rhumatoïde, ainsi que divers types de cancers peuvent être traités ou prévenus par l'utilisation d'un agent qui augmente sélectivement la production de la 15-désoxy-prostaglandine J2.

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