Modulation of secondary metabolite production by zinc...

Details Modulation of secondary metabolite production by zinc... Modulation of secondary metabolite production by zinc...

C - Chemistry, Metallurgy

12

P

C12P 1/02 (2006.01) C07K 14/37 (2006.01) C12N 1/15 (2006.01) C12N 15/80 (2006.01) C12P 7/42 (2006.01) C12P 17/06 (2006.01) C12P 35/00 (2006.01) C12P 35/06 (2006.01) C12P 37/00 (2006.01)

Patent

CA 2422730

Disclosed are methods for the modulation of secondary metabolite production by fungi through genetic manipulation of such fungi. Also disclosed are new commercial processes using ZBC proteins, or variants thereof, to significantly increase useful secondary metabolite production. Generally, the methods according to the invention comprise expressing in a fungus a ZBC protein or a variant thereof.

L'invention concerne des procédés de modulation de la production de métabolites secondaires par des champignons, par manipulation génétique de ces champignons. L'invention concerne également des nouveaux procédés commerciaux mettant en oeuvre des protéines ZBC (protéines en bouquet binucléaire à zinc), ou des variants de celles-ci, et consistant à accroître de manière importante la production de métabolites secondaires. En général, les procédés selon l'invention comprennent l'expression dans un champignon d'une protéine ZBC ou d'un variant de celle-ci.

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